Category: fragment
The kinome navigator
In a recent paper, Metz et al. describe a statistical framework for constructing the kinome polypharmacology network. Using a large kinase panel (i.e., more than 150,000 activity values across 172 kin... Read More
Fragment activity profiler
A challenging task in early stage lead discovery is the triaging of chemical series from high throughput screening (HTS) assays. Here triaging is a multiplex problem that seeks to find the balance b... Read More