Persona lets you log in to websites using only your email address! Persona lets you prove your identity to websites through your email address without giving them any passwords. This works similarly to how you prove your identity when you show someone your ID: websites can easily verify that your ID is authentic and that you really are the person it was issued to.
Most people are exposed to many different chemicals during the course of their lifetimes through sources including food, household cleaning products and medicines. In some cases, these chemicals can be toxic.
In fact, more than 30 percent of promising pharmaceuticals have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in animal models (Nat Rev Drug Discov. 2004;3(8):711–715). Creating new methods for assessing chemical toxicity has the potential to improve how scientists evaluate environmental chemicals and develop new medicines.
The Toxicology in the 21st Century (Tox21) program, a federal collaboration involving NIH, the Environmental Protection Agency, and the Food and Drug Administration, is aimed at developing better toxicity assessment methods. The goal is to quickly and efficiently test whether certain chemical compounds have the potential to disrupt processes in the human body that may lead to adverse health effects.
The Tox21 consortium leverages its partners' resources and expertise to predict more effectively how a collection of 10,000 compounds composed of environmental chemicals and approved drugs will affect human health and the environment.
The goal of the challenge is to "crowdsource" data analysis by independent researchers to reveal how well they can predict compounds' interference in biochemical pathways using only chemical structure data. The computational models produced from the Challenge could become decision-making tools for government agencies in determining which environmental chemicals and drugs are of the greatest potential concern to human health.
Use data generated from nuclear receptor signaling and stress pathway assays run against Tox21's 10,000-compound library (Tox21 10K) to build models and look for structure-activity relationships.
Participants have the opportunity to join 15 distinct subchallenges:
Participants can choose to join one or all of the subchallenges. There will be one winner for each subchallenge.
Predict the compound activity outcome (active or inactive) in one or more of the 12 pathway assays based on the chemical structure information for the following assays:
Predict compound activity in all nuclear receptor signaling pathways.
Predict compound activity in all stress response pathways.
Predict compound activity in all of the above-mentioned assays, collectively.