Recently Bruns & Watson published a paper describing a set of rules to filter out (potenially) reactive and promiscuous small molecules. There are 275 rules addressing a variety of possible reason...Read More
In a recent paper, Metz et al. describe a statistical framework for constructing the kinome polypharmacology network. Using a large kinase panel (i.e., more than 150,000 activity values across 172 kin...Read More
A challenging task in early stage lead discovery is the triaging of chemical series from high throughput screening (HTS) assays. Here triaging is a multiplex problem that seeks to find the balance b...Read More
Molecular framework forms the basis for which compounds are organized, indexed, and visualized within Tripod. There are two types of framework currently being generated when compounds are registered...Read More